MycoWeekly Newsletter

Your Weekly Dose of Mycology Research

Antibody response to microbiota antigens is associated with alcohol-related liver disease severity and predicts mortality.

2025-07-01
Hepatology • Level 3 (12 panels)
A. Putignano, Natasha S Kelkar, Dalila Lakhloufi, Shilpee Sharma, Anais Thiriard, Yiwei Jiang, Dansala Welba, Christophe Moreno, Samuel Meurée, D. Degré, Patrice Filee, A. Botteaux, M. E. Ackerman, T. Gustot, Arnaud Marchant

In alcohol-related liver disease (ALD), dysbiosis leads to gut microbiota components activating immune responses. A study of 207 ALD patients revealed microbiota-specific antibodies correlate with disease severity, particularly those against Staphylococcus aureus and Candida albicans. These antibodies predict severe outcomes, suggesting potential as biomarkers for ALD management.

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Light controls gene functions through alternative splicing in fungi.

2025-07-01
Proceedings of the National Academy of Sciences of the United States of America • Level 3 (24 panels)
Yifan Li, Huanhong Lu, Degang Guo, Xiaoyan Li, Fei Qi, Jian Zhang, Reinhard Fischer, Qirong Shen, Zhenzhong Yu

This study reveals how light, beyond influencing gene transcription, regulates alternative splicing (AS) in fungi like Aspergillus nidulans. In Trichoderma guizhouense, blue light-driven AS, mediated by the receptor BLR1 and the MAPK HOG pathway, impacts ergothioneine biosynthesis and conidiation. The pathway activates SRK1, which enters the nucleus to modulate AS, highlighting a novel environmental sensing mechanism in fungi.

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Heritable symbiont producing nonribosomal peptide confers extreme heat sensitivity and antifungal protection on its host.

2025-06-26
Proceedings of the National Academy of Sciences of the United States of America • Level 3 (24 panels)
Gerald P. Maeda, Vy Dang, Mary Katherine Kelly, Aadhunik Sundar, Ryan L. W. Arnott, Edward M. Marcotte, N. Moran

This study examines the symbiosis between pea aphids and the bacterial endosymbiont, Fukatsuia symbiotica, focusing on a nonribosomal peptide synthesis pathway. The symbiont confers antifungal protection while causing extreme heat sensitivity and developmental disruptions, linked to a peptide similar to Herbicolin A. This highlights a complex trade-off impacting host fitness.

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Overcoming toxicity: How nonantagonistic microbes manage to thrive in boom-and-bust environments.

2025-06-26
Proceedings of the National Academy of Sciences of the United States of America • Level 3 (24 panels)
MingYi Wang, Alexander Vladimirsky, A. Giometto

In microbial ecology, antagonistic interactions involve microbes producing toxins to eliminate rivals, typically dominating lab environments. However, a study using Saccharomyces cerevisiae demonstrates that in natural "boom-and-bust" environments, nonantagonistic strains thrive without the costly toxin production. These microbes benefit particularly during unpredictable environmental fluctuations, highlighting diverse survival strategies.

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