MycoWeekly Newsletter

Your Weekly Dose of Mycology Research

Proton-Detected Solid-State NMR for Deciphering Structural Polymorphism and Dynamic Heterogeneity of Cellular Carbohydrates in Pathogenic Fungi.

2025-05-06
Journal of the American Chemical Society • Level 3 (4 panels)
Jayasubba Reddy Yarava, Isha Gautam, Anand Jacob, Riqiang Fu, Tuo Wang

Proton-detection solid-state NMR spectroscopy, essential for resolving structural complexities in biomolecules, elucidates carbohydrate diversity in pathogenic fungi. This study reveals 15 chitin forms in Rhizopus delemar, five α-1,3-glucan forms in Aspergillus fumigatus, and eight α-1,2-mannan variants in Candida albicans, offering insights into fungal cell wall dynamics and structural integrity.

Read full paper

Soybean productivity can be enhanced by understanding rhizosphere microbiota: evidence from metagenomics analysis from diverse agroecosystems

2025-04-26
Microbiome • Level 3 (7 panels)
Honglei Ren, Huilong Hong, Bire Zha, S. F. Lamlom, Hongmei Qiu, Yongqiang Cao, Rujian Sun, Haorang Wang, Junkui Ma, Hengbin Zhang, Liping Sun, Qing Yang, Changjun Zhou, Xiulin Liu, Xueyang Wang, Chunlei Zhang, Fengyi Zhang, Kezhen Zhao, Rongqiang Yuan, A. M. Abdelghany, Bixian Zhang, Yuhong Zheng, Jiajun Wang, Wencheng Lu

This study explores the rhizosphere microbiota of soybeans across 13 Chinese locations, employing metagenomics to identify 43,337 microbial species impacting crop productivity. Significant site-specific microbial diversity and community composition variations were found, with key bacteria enhancing nutrient cycling and correlating with increased soybean yields.

Read full paper

Bayesian phylodynamic inference of population dynamics with dormancy.

2025-05-02
Proceedings of the National Academy of Sciences of the United States of America • Level 3 (24 panels)
Lorenzo Cappello, Wai Tung ‘Jack’ Lo, Joy Z. Zhang, Peiyu Xu, Daniel Barrow, Ishani Chopra, Andrew G. Clark, Martin T. Wells, Jaehee Kim

Dormancy, a survival strategy in fluctuating environments, significantly impacts genetic diversity in organisms, including fungi. This study introduces a Bayesian framework to infer population dynamics involving dormancy using sequence data. By focusing on the strong seedbank coalescent, the researchers provide novel computational tools integrated into BEAST2, aiding in the analysis of fungal ecoevolutionary processes.

Read full paper

A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite-CerS6-ceramide axis.

2025-05-01
Science • Level 3 (24 panels)
Shuang Zhou, Meng Li, Pengcheng Wang, Chenghao Guo, Jinxin Zhang, Xi Luo, Yu-Chen Fan, Enqiang Chen, Xingshun Qi, Jinjun Chen, Lechi Ye, Hai-Yang Yuan, Wen-Bing Yin, Kai Wang, M. Zheng, Yanli Pang, Jie Qiao, Changtao Jiang

This study identifies Fusarium foetens as a symbiotic gut fungus in mice, providing insight into its therapeutic potential. Researchers discovered FF-C1, a secondary metabolite that acts as a CerS6 inhibitor, revealing its endogenous role in mitigating the progression of MASH. These findings highlight the impact of fungal metabolites on host metabolic pathways, expanding the scope of gut mycology research.

Read full paper